Keyword Analysis & Research: cyclosporine moa
Keyword Research: People who searched cyclosporine moa also searched
Search Results related to cyclosporine moa on Search Engine
-
Cyclosporine: Uses, Interactions, Mechanism of Action
https://go.drugbank.com/drugs/DB00091
WEBCyclosporine is a calcineurin inhibitor that inhibits T cell activation. 2,5,12 Its binding to the receptor cyclophilin-1 inside cells produces a complex known as cyclosporine-cyclophilin. This complex subsequently inhibits calcineurin, which in turn stops the dephosphorylation as well as the activation of the nuclear factor of activated T ...
DA: 10 PA: 78 MOZ Rank: 13
-
Cyclosporine - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK482450/
WEBAug 28, 2023 · Cyclosporine is an immunosuppressive agent used to treat organ rejection post-transplant. It also has uses in certain other autoimmune diseases. [1] [2] [3] [4] [5] FDA approved Indications. In solid organ transplantation, it has clinical use to treat organ rejection in kidney, liver, and heart allogeneic transplants.
DA: 42 PA: 90 MOZ Rank: 72
-
A Review of the Mechanism of Action of Cyclosporine A: The Role …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719434/
WEBDec 2, 2020 · This review covers the immunopathophysiology of DED as well as the mechanism of action of cyclosporine A and its role in modulating ocular inflammation, compares the current ophthalmic cyclosporine A formulations, and discusses the limitations and challenges of using cyclosporine A for the treatment of DED. Go to:
DA: 10 PA: 87 MOZ Rank: 48
-
Mechanisms of action of cyclosporine - PubMed
https://pubmed.ncbi.nlm.nih.gov/10878286/
WEBCalcineurin. Cyclosporine (cyclosporin A, CsA) has potent immunosuppressive properties, reflecting its ability to block the transcription of cytokine genes in activated T cells. It is well established that CsA through formation of a complex with cyclophilin inhibits the phosphatase activity of calcineurin, which ….
DA: 17 PA: 36 MOZ Rank: 93
-
Pharmacology of cyclosporine and tacrolimus - UpToDate
https://www.uptodate.com/contents/pharmacology-of-cyclosporine-and-tacrolimus
WEBJan 24, 2024 · Cyclosporine is a lipophilic cyclic peptide of 11 amino acids, while tacrolimus is a macrolide antibiotic. Both drugs have been isolated from fungi and possess similar suppressive effects on cell-mediated and humoral immune responses.
DA: 64 PA: 60 MOZ Rank: 80
-
Cyclosporine: mechanisms of action and toxicity
https://www.ccjm.org/content/ccjom/61/4/308.full.pdf
WEBCyclosporine and related agents such as FK-506 and rapamycin selectively inhibit adaptive immune responses by blocking T cell-dependent biosynthesis of lymphokines, particularly interleukin 2 at the level of messenger ribonucleic acid (mRNA) transcription.
DA: 93 PA: 48 MOZ Rank: 38
-
Ciclosporin - Wikipedia
https://en.wikipedia.org/wiki/Ciclosporin
WEBCiclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, eczema, and in …
DA: 66 PA: 47 MOZ Rank: 64
-
Cyclosporine: mechanisms of action and toxicity
https://www.ccjm.org/content/61/4/308
WEBJul 1, 1994 · Cyclosporine: mechanisms of action and toxicity. Robert M. Graham, MD. Cleveland Clinic Journal of Medicine July 1994, 61 (4) 308-313; Article. Info & Metrics. PDF. ABSTRACT. BACKGROUND Newer immunosuppressive agents are permitting transplantation to be performed more frequently.
DA: 41 PA: 24 MOZ Rank: 25
-
The Mechanisms of Action of Cyclosporine - Immunology and …
https://www.immunology.theclinics.com/article/S0889-8561(22)00589-6/fulltext
WEBThe Mechanisms of Action of Cyclosporine. This paper is only available as a PDF. To read, Please Download here. SUMMARY. CS most probably manifests its immunosuppressive effects by inhibiting the synthesis of IL-2 and other lymphokine mRNAs during the process of T-cell activation.
DA: 49 PA: 97 MOZ Rank: 75
-
The Mechanisms of Action of Cyclosporine - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S0733865118303874
WEBFeb 1, 1990 · Cyclosporine (CS) is a key immunosuppressive agent in clinical transplantation. The cellular target for CS is the CD4 lymphocyte and the drug prevents the function of this cell by inhibiting the synthesis of mRNAs for lymphokines. However, the precise molecular mechanisms by which CS achieves its effects is unknown.
DA: 16 PA: 26 MOZ Rank: 4
