Gnas.site - GNAS gene: MedlinePlus Genetics
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WEBThe GNAS gene provides instructions for making one component, the stimulatory alpha subunit, of a protein complex called a guanine nucleotide-binding protein (G protein). Learn about this gene and related health conditions.
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GNAS gene: MedlinePlus Genetics
https://medlineplus.gov/genetics/gene/gnas/
WEBThe GNAS gene provides instructions for making one component, the stimulatory alpha subunit, of a protein complex called a guanine nucleotide-binding protein (G protein). Learn about this gene and related health conditions.
DA: 72 PA: 78 MOZ Rank: 74
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GNAS Gene - GeneCards | GNAS3 Protein | GNAS3 Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GNAS
WEBApr 3, 2024 · GNAS (GNAS Complex Locus) is a Protein Coding gene. Diseases associated with GNAS include Mccune-Albright Syndrome and Osseous Heteroplasia, Progressive. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and GPCR Pathway.
DA: 24 PA: 84 MOZ Rank: 11
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GNAS complex locus - Wikipedia
https://en.wikipedia.org/wiki/GNAS_complex_locus
WEBGNAS complex locus is a gene locus in humans. Its main product is the heterotrimeric G-protein alpha subunit G s-α, a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways. GNAS stands for Guanine Nucleotide binding protein, Alpha Stimulating activity polypeptide.
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Disorders of GNAS Inactivation - GeneReviews® - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK459117/
WEBOct 26, 2017 · A disorder of GNAS inactivation should be suspected in individuals with the following phenotypes. Pseudohypoparathyroidism Ia (PHP-Ia) and pseudohypoparathyroidism Ic (PHP-Ic). The most readily recognized form of PHP is PHP-Ia, which has clinical and endocrine features similar to PHP-Ic.
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Minireview: GNAS : Normal and Abnormal Functions - Oxford …
https://academic.oup.com/endo/article/145/12/5459/2499741
WEBDec 1, 2004 · GNAS is a complex imprinted gene that uses multiple promoters to generate several gene products, including the G protein α-subunit (G s α) that couples seven-transmembrane receptors to the cAMP-generating enzyme adenylyl cyclase.
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GNAS spectrum of disorders - PMC - National Center for …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417430/
WEBThe GNAS gene, located on the long arm of chromosome 20 in humans [ 1 ], gives rise to multiple gene products, including transcripts that encode the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gsα), extra-large Gsα (XLαs), and neuroendocrine secretory protein 55 (NESP55) [ 2 – 5] ( Fig. 1 ).
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Obesity-Associated GNAS Mutations and the Melanocortin Pathway
https://www.nejm.org/doi/full/10.1056/NEJMoa2103329
WEBOct 6, 2021 · Conclusions. Because pathogenic mutations may manifest with obesity alone, screening of children with severe obesity for GNAS deficiency may allow early diagnosis, improving clinical outcomes,...
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GNAS shifts metabolism in pancreatic cancer - Nature
https://www.nature.com/articles/s41556-018-0120-5
WEBJun 25, 2018 · Concurrent G-protein α s (GNAS) and KRAS mutations in a subset of pancreatic tumours are now shown to inhibit SIK kinases through aberrant cAMP–PKA activation, triggering a metabolic...
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GNAS locus: bone related diseases and mouse models
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1255864/full
WEBOct 17, 2023 · The GNAS locus, encompassing Gsα, XLαs, and other products, exerts profound influence over a variety of physiological processes through regulating multitude signaling pathways. Among these, the regulation on …
DA: 45 PA: 23 MOZ Rank: 52
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GNAS locus: bone related diseases and mouse models - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619756/
WEBOct 18, 2023 · The GNAS locus, encompassing Gsα, XLαs, and other products, exerts profound influence over a variety of physiological processes through regulating multitude signaling pathways. Among these, the regulation on …
DA: 16 PA: 77 MOZ Rank: 14
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