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What is cAd3-ZEBOV?

cAd3-ZEBOV (also known as the NIAID/GSK Ebola vaccine or cAd3-EBO Z) is an experimental vaccine for two ebolaviruses, Ebola virus and Sudan virus, developed by scientists at GlaxoSmithKline (GSK) and tested by National Institute of Allergy and Infectious Disease (NIAID).

What is rVSV-ZEBOV?

rVSV-ZEBOV is a live, attenuated recombinant vesicular stomatitis virus in which the gene for the native envelope glycoprotein ( P03522) is replaced with that from the Ebola virus ( P87666 ), Kikwit 1995 Zaire strain. Manufacturing of the vaccine for the Phase I trial was done by IDT Biologika.

What does ZEBOV-GP stand for?

The VSV glycoprotein gene was deleted (rVSVΔG) and ZEBOV glycoprotein (GP) was inserted into the deleted VSV glycoprotein open reading frame (ORF) resulting in a live, replication-competent vector (rVSVΔG-ZEBOV-GP).

Is the rVSV-ZEBOV vaccine for Ebola disease possible in humans?

Ebola virus disease is an urgent international priority. Promising results for several vaccine candidates have been reported in non-human primate studies and clinical trials with the most promising being the rVSV-ZEBOV vaccine. In this study, we sought to produce rVSV-ZEBOV in HEK 293SF cells in suspension and serum-free media.


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