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The status of tuberculosis vaccine development - PubMed
https://pubmed.ncbi.nlm.nih.gov/32014117/
The spread of strains resistant to multiple drugs adds additional urgency to the vaccine development effort yet attempts to develop new vaccines with wider applicability and better, longer-lasting efficacy than BCG-the only tuberculosis vaccine licensed for use globally-have proven challenging. Author: Lewis K Schrager, Johan Vekemens, Nick Drager, David M Lewinsohn, Ole F Olesen Publish Year: 2020
Author: Lewis K Schrager, Johan Vekemens, Nick Drager, David M Lewinsohn, Ole F Olesen
Publish Year: 2020
DA: 17 PA: 43 MOZ Rank: 14
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Tuberculosis vaccine development: from classic to clinical candidates
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223099/
Author: Junli Li, Aihua Zhao, Jun Tang, Guozhi Wang, Yanan Shi, Lingjun Zhan, Chuan Qin Publish Year: 2020
Author: Junli Li, Aihua Zhao, Jun Tang, Guozhi Wang, Yanan Shi, Lingjun Zhan, Chuan Qin
Publish Year: 2020
DA: 21 PA: 76 MOZ Rank: 33
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Tuberculosis Vaccine Development | NIH: National Institute of …
https://www.niaid.nih.gov/diseases-conditions/tuberculosis-vaccine-development
Oct 27, 2016 · Tuberculosis Vaccine Development NIAID is part of the global research community engaged in finding new ways to prevent tuberculosis (TB) disease in children and adults. In addition to developing new approaches for treatment of people who are infected but have not yet developed disease, researchers are also trying to understand how the TB …
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Vaccine Development Against Tuberculosis Over the Last 140 …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526900/
Oct 06, 2021 · The 30 years between 1890, when Koch had first announced his vaccine against TB, and 1921, when Albert Calmette (1863–1933) and Camille Guérin (1872–1961) administered BCG to a human neonate for the first time, were characterized by the development and clinical testing of different vaccine types including subunit vaccines, inactivated vaccines and live … Author: Stefan H. E. Kaufmann, Stefan H. E. Kaufmann Publish Year: 2021
Author: Stefan H. E. Kaufmann, Stefan H. E. Kaufmann
Publish Year: 2021
DA: 61 PA: 64 MOZ Rank: 15
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Tuberculosis Vaccine Development: Progress in Clinical Evaluation
https://pubmed.ncbi.nlm.nih.gov/31666281/
These breakthroughs, based on the greatly expanded knowledge of the M. tuberculosis infection spectrum, immunology of TB, and vaccine platforms, have reinvigorated the TB vaccine field. Here, we review our current understanding of natural immunity to TB, limitations in BCG immunity that are guiding vaccinologists to design novel TB vaccine candidates and concepts, and the … Author: Suraj B. Sable, James E. Posey, Thomas J. Scriba, Thomas J. Scriba Publish Year: 2019
Author: Suraj B. Sable, James E. Posey, Thomas J. Scriba, Thomas J. Scriba
Publish Year: 2019
DA: 40 PA: 24 MOZ Rank: 4
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Tuberculosis vaccines - Wikipedia
https://en.wikipedia.org/wiki/Tuberculosis_vaccines
Tuberculosis ( TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch. [1] Today, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921. [2]
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The status of tuberculosis vaccine development
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30625-5/fulltext
new vaccine capable of preventing tuberculosis, particularly in adolescents and adults. The spread of strains resistant to multiple drugs adds additional urgency to the vaccine development effort yet attempts to develop new vaccines with wider applicability and better, longer-lasting efficacy than BCG—the only tuberculosis vaccine licensed for
DA: 70 PA: 38 MOZ Rank: 21
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Insights and challenges in tuberculosis vaccine development
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(19)30274-7/fulltext
Tuberculosis vaccine development is difficult and slow. Substantial progress has been made in research and development of tuberculosis vaccines in the past 20 years, and two clinical trial results from 2018 provide reason for optimism. However, many challenges to the successful licensure and deployment of an effective tuberculosis vaccine remain.
DA: 91 PA: 46 MOZ Rank: 13
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TB vaccine development: where are we and why is it so difficult?
https://thorax.bmj.com/content/70/3/299
TB vaccine development begins with an understanding of the type of immune response required for protective immunity. For many vaccine preventable infectious diseases, protection is conveyed through attaining sterilising immunity either from natural exposure to the pathogen or by vaccine induced neutralising antibody production.
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Development of New Vaccines for Tuberculosis - Centers for …
https://www.cdc.gov/mmwr/PDF/rr/rr4713.pdf
PROGRESS IN VACCINE DEVELOPMENT A major research effort is being made to develop new tuberculosis vaccines. Much of this work is aimed at improved understanding of the i mmunopathogenesis of TB by studying both the infecting organism and its human host.
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