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Tumor necrosis factor - Wikipedia
https://en.wikipedia.org/wiki/Tumor_necrosis_factor
WEBTumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain. TNF signaling occurs through two receptors: TNFR1 and TNFR2.
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The Role of Tumor Necrosis Factor Alpha (TNF-α) in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962638/
WEBMar 8, 2021 · Tumor necrosis factor alpha (TNF-α) is a cytokine that has pleiotropic effects on various cell types. It has been identified as a major regulator of inflammatory responses and is known to be involved in the pathogenesis of some inflammatory and autoimmune diseases [ 1 ].
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Tumor Necrosis Factor Alpha - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/tumor-necrosis-factor-alpha
WEBTumour necrosis factor α (TNFα) is a potent paracrine and endocrine mediator of inflammatory and immune functions. It is also known to regulate growth and differentiation of a wide variety of cells types. TNFα is selectively cytotoxic for many transformed cells, especially in combination with IFNα.
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Tumor Necrosis Factor Inhibitors - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK482425/
WEBJul 3, 2023 · Continuing Education Activity. Tumor necrosis factor (TNF)-alpha inhibitors, including etanercept (E), infliximab (I), adalimumab (A), certolizumab pegol (C), and golimumab (G), are biologic agents which are FDA-approved to treat ankylosing spondylitis (E, I, A, C, and G), Crohn disease (I, A and C), hidradenitis suppurativa (A), juvenile ...
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Tumor necrosis factor-alpha inhibitors: An overview of ... - UpToDate
https://www.uptodate.com/contents/tumor-necrosis-factor-alpha-inhibitors-an-overview-of-adverse-effects
WEBJan 23, 2024 · Inhibitors of tumor necrosis factor (TNF)-alpha are important treatments in a number of inflammatory conditions, including rheumatoid arthritis (RA), spondyloarthritis, psoriasis, and inflammatory bowel disease (IBD).
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Metabolic Messengers: tumour necrosis factor | Nature Metabolism
https://www.nature.com/articles/s42255-021-00470-z
WEBOct 14, 2021 · Tumour necrosis factor alpha (TNF-α), also known as TNF superfamily member 2 (TNFSF2) or simply TNF, is a multifunctional cytokine that has well-established immunological roles in innate...
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Tumour necrosis factor signalling in health and disease - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352924/
WEBJan 28, 2019 · TNF plays a vital role in the typical immune response through the regulation of a number of pathways encompassing an immediate inflammatory reaction with significant innate immune involvement as well as cellular activation with subsequent proliferation and programmed cell death or necrosis.
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TNF alpha and the TNF receptor superfamily: structure-function ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/10891884/
WEBAug 1, 2000 · TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. Both these receptors belong to the so-called TNF receptor superfamily. The superfamily includes FAS, CD40, CD27, and RANK.
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Insights into the biology and therapeutic implications of TNF and
https://www.nature.com/articles/s41584-021-00639-6
WEBJul 5, 2021 · Article 02 November 2021. Targeting interferon-γ in hyperinflammation: opportunities and challenges. Article 05 October 2021. Introduction. Tumour necrosis factor (TNF) is an inflammatory...
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The Role of Tumor Necrosis Factor Alpha (TNF-α) in …
https://pubmed.ncbi.nlm.nih.gov/33800290/
WEBMar 8, 2021 · PMCID: PMC7962638. DOI: 10.3390/ijms22052719. Abstract. Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases.
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