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S100B - Wikipedia
https://en.wikipedia.org/wiki/S100B
webS100 calcium-binding protein B (S100B) is a protein of the S-100 protein family. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.
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Usefulness of S100B protein in neurological disorders - PubMed
https://pubmed.ncbi.nlm.nih.gov/21465945/
webThe S100B is a calcium-binding peptide and is used as a parameter of glial activation and/or death in many disorders of the central nervous system (CNS). It plays important roles in normal CNS development and recovery after injury.
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The S100B Protein: A Multifaceted Pathogenic Factor More Than a
https://pubmed.ncbi.nlm.nih.gov/37298554/
webMay 31, 2023 · S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system. Its levels in biological fluids are recognized as a reliable biomarker of active neural distress, and more recently, mounting evidence points to S100B as a Damage-Associated Molecular Pattern molecule, which, ….
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Mini review: Current status and perspective of S100B protein as a
https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-023-00807-2
webJul 20, 2023 · S100B is a calcium-binding protein, widely expressed in the brain predominantly by astrocytes, but also by maturing oligodendrocytes, neural progenitor cells, dendritic cells and specific lymphocyte subpopulations. S100B can be released extracellularly and is considered as a marker of brain damage . Many studies have related S100B to a ...
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Targeting S100B Protein as a Surrogate Biomarker and its Role in
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033985/
webS100B is a helix-loop-helix protein with the calcium-binding domain associated with various neurological disorders through activation of the MAPK pathway, increased NF-kB expression resulting in cell survival, proliferation and gene up-regulation.
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A review of the clinical utility of serum S100B protein levels in the
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241347/
webDec 12, 2016 · S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis. Brain Res. 1998; 813 :211–217. doi: 10.1016/S0006-8993(98)01014-2.
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Serum S100B protein as a marker of severity in Covid-19 patients
https://www.nature.com/articles/s41598-020-75618-0
webOct 29, 2020 · We focused on S100B, a calcium-binding protein present in biological fluids, being a reliable biomarker in disorders having inflammatory processes as common basis and RAGE as main receptor.
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Structural Basis for S100B Interaction with its Target Proteins
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405260/
webCurrently S100B has been reported to interact with a variety of protein targets including the p53 tumor suppressor, CapZ, the RAGE receptor, NDR kinase, neurotensin, cathepsin L inhibitor, Hdm2, Hdm4, protein kinase Cα, ROS-GC1, microtubule-associated tau proteins, melittin, amyloid-β, interleukin-11, the serotonin 5-HT7 receptor, the ...
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S100 proteins in cancer | Nature Reviews Cancer
https://www.nature.com/articles/nrc3893
webJan 23, 2015 · Key Points. The S100 protein family is composed of 21 members that exhibit a high degree of structural similarity, but are not functionally interchangeable. S100 family members function as...
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S100B protein: general characteristics and pathophysiological …
https://pubmed.ncbi.nlm.nih.gov/32772615/
webS100 Calcium Binding Protein beta Subunit. In-depth studies are necessary to discover the innumerable actions of this protein which are still unknown. It is expected that these can bring varied benefits by elucidating its therapeutic potential in preclinical and clinical situations.
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