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S100A8 Gene - GeneCards | S10A8 Protein | S10A8 Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=S100A8
Web ResultJan 3, 2024 · S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions.
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S100A8 - Wikipedia
https://en.wikipedia.org/wiki/S100A8
Web ResultS100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. It is also known as calgranulin A. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding …
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S100A8/A9: From basic science to clinical application - PubMed
https://pubmed.ncbi.nlm.nih.gov/27492899/
Web ResultBesides its biological function, S100A8/A9 (also known as myeloid related protein 8/14, MRP8/14) was identified as interesting biomarker to monitor disease activity in chronic inflammatory disorders including inflammatory bowel disease and …
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S100A8/A9 as a prognostic biomarker with causal effects for
https://www.nature.com/articles/s41467-024-46973-7
Web Result1 day ago · Here, we show that S100A8/A9 is a predictor and potentially causal medicator for heart failure post-acute myocardial infarction. Heart failure is the most prevalent complication of acute ...
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S100A8/A9 in Inflammation - PubMed
https://pubmed.ncbi.nlm.nih.gov/29942307/
Web ResultJun 11, 2018 · During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of …
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Frontiers | S100A8/A9 in Inflammation
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01298/full
Web ResultIn view of its vital role in the physiology of inflammation, S100A8/A9 is a valuable candidate as both a diagnostic biomarker and therapeutic target for inflammation-associated diseases, and its potential in clinical applications is worthy of further exploration. Expression and Distribution of S100A8/A9.
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S100A8/A9 Is a Marker for the Release of Neutrophil ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/35053354/
Web ResultJan 11, 2022 · We observed that S100A8/A9 is highly present in the cytoplasmic fraction of neutrophils and is not part of the granule content. Furthermore, we found that S100A8/A9 was not released in parallel with granular content but upon the formation of neutrophil extracellular traps (NETs).
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The functions and regulatory pathways of S100A8/A9 and its …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493297/
Web ResultAug 28, 2023 · S100A8/A9, a heterodimer protein mainly generated by neutrophils, triggers many signal transduction pathways to mediate microtubule constitution and pathogen defense, as well as intricate procedures of cancer growth, metastasis, drug resistance, and prognosis.
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S100A8 promotes migration and infiltration of inflammatory
https://www.nature.com/articles/srep36140
Web ResultOct 27, 2016 · S100A8 is a calcium-binding protein which mainly expresses in granulocytes and monocytes and plays a prominent role in the regulation of inflammatory processes and immune response. Here, we...
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S100A8 as a Promising Biomarker and Oncogenic Immune …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132702/
Web ResultMar 18, 2022 · S100A8 is associated with immune cell infiltration, immunological modulators, and immunotherapeutic indicators. S100A8 overexpression is connected to immune-related pathways. However, no statistically significant connection between S100A8 and immunotherapeutic response was identified. Conclusions.
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