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S100 protein - Wikipedia
https://en.wikipedia.org/wiki/S100_protein
The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known. They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3.
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S100 proteins: structure, functions and pathology - PubMed
https://pubmed.ncbi.nlm.nih.gov/11991838/
May 1, 2002 · S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation. Twenty members have been identified so far, and altogether, S100 proteins represent the largest subgroup in the EF-hand Ca2+ …
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Functions of S100 Proteins - PMC - National Center for …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707951/
The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects.
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S100 proteins in cancer | Nature Reviews Cancer
https://www.nature.com/articles/nrc3893
BMC Cancer (2023) The S100 family of proteins modulates cellular responses by acting both as intracellular Ca2+sensors and as extracellular factors. Expression of several members of this family...
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Multifunctional Role of S100 Protein Family in the Immune …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332480/
Jul 23, 2022 · The S100 protein is primarily involved in embryo adhesion/implantation, endometrial receptivity, immune tolerance, prolactin secretion, and endometrial epithelial cell apoptosis, implying conclusively that it is a hallmark marker for the onset of decasualization .
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Role of S100 proteins in health and disease - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S0167488920300355
Jun 1, 2020 · Assessment of S100 protein structure, function, and expression. • Mechanism of action of S100 proteins in disease pathophysiology. • S100 proteins as biomarkers for disease detection and prognosis. • Therapeutic strategies targeting S100 proteins to treat disease.
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Role of S100 proteins in health and disease - PubMed
https://pubmed.ncbi.nlm.nih.gov/32057918/
Abstract. The S100 family of proteins contains 25 known members that share a high degree of sequence and structural similarity. However, only a limited number of family members have been characterized in depth, and the roles of other members are likely undervalued.
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S100 Proteins As an Important Regulator of Macrophage …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770888/
Jan 5, 2018 · The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation.
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S100 family proteins in inflammation and beyond - PubMed
https://pubmed.ncbi.nlm.nih.gov/32564786/
Abstract. The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskeleton and microbial resistance.
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Frontiers | S100 Proteins As an Important Regulator of …
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01908/full
Jan 4, 2018 · The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation.
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