Keyword Analysis & Research: phenotypic screening
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Phenotypic screening - Wikipedia
https://en.wikipedia.org/wiki/Phenotypic_screening
WebPhenotypic screening is a type of screening used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell or an organism in a desired manner.
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Phenotypic drug discovery: recent successes, lessons learned
https://www.nature.com/articles/s41573-022-00472-w
WebMay 30, 2022 · Phenotypic screening offers the possibility to identify hits with novel, unbiased polypharmacology signatures only limited by the target landscape of the model system and the number of...
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Phenotypic screening - Latest research and news | Nature
https://www.nature.com/subjects/phenotypic-screening
WebApr 12, 2024 · Phenotypic screening is a strategy for the identification of molecules with particular biological effects in cell-based assays or animal models. For example, it can...
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Opportunities and challenges in phenotypic drug discovery: an
https://www.nature.com/articles/nrd.2017.111
WebJul 7, 2017 · Although there is clear evidence that phenotypic screening can be an attractive proposition for efficiently identifying functionally active hits that lead to first-in-class drugs, the gap...
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Phenotypic Drug Discovery: Recent successes, lessons learned …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708951/
WebModern phenotypic drug discovery (PDD) combines the original concept with modern tools and strategies, and has re-emerged over the past decade to systematically pursue drug discovery based on therapeutic effects in realistic disease models. Here, we discuss recent successes, as well as consider ongoing challenges and approaches to address them.
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Phenotypic Screening - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/phenotypic-screening
WebPhenotypic screening provides a nonbiased approach to chemically interrogate the proteome in its pathophysiologically-relevant environment, and accordingly increase the chances of revealing authentic disease mechanisms and identifying potential therapies.
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Phenotypic screens as a renewed approach for drug discovery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531371/
WebPhenotypic screening is thus gaining new momentum in drug discovery with the hope that this approach may revitalize drug discovery and improve the success rate of drug approval through the discovery of viable lead compounds and identification of novel drug targets.
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The future of phenotypic drug discovery: Cell Chemical Biology
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(21)00010-6
WebFeb 1, 2021 · Considerations for phenotypic assays for primary screening. The goal of primary screening in PDD is the discovery of chemical matter (or other modalities) that will modulate relevant disease biology. This can be challenging if the biology is …
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Back to the Future with Phenotypic Screening - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102969/
WebJul 7, 2014 · Phenotypic screening is defined as drug screening in cellular or animal disease models to identify compounds that modify the phenotype in such a way as to generate a positive outcome relative to the disease.
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Phenotypic screening: the future of antibody discovery - PubMed
https://pubmed.ncbi.nlm.nih.gov/26440132/
WebAbstract. Most antibody therapeutics have been isolated from high throughput target-based screening. However, as the number of validated targets diminishes and the target space becomes increasingly competitive, alternative strategies, such as phenotypic screening, are gaining momentum.
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