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Human cell based directed evolution of adenine base editors ... - Nature
https://www.nature.com/articles/s41467-021-26211-0
WEBOct 8, 2021 · Nature Communications - Application of adenine base editors (ABE) has been precluded by low activity. Here the authors show the generation of a human cell based ABE directional screening...
DA: 95 PA: 21 MOZ Rank: 31
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Adenine base editor engineering reduces editing of bystander ... - Nature
https://www.nature.com/articles/s41587-021-00943-2
WEBJul 1, 2021 · Nature Biotechnology (2023) Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of interest. However, ABEs also induce cytosine deamination at the target site.
DA: 36 PA: 12 MOZ Rank: 64
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In vivo adenine base editing of PCSK9 in macaques reduces LDL ... - Nature
https://www.nature.com/articles/s41587-021-00933-4
WEBMay 19, 2021 · … Gerald Schwank. Show authors. Nature Biotechnology 39 , 949–957 ( 2021) Cite this article. 33k Accesses. 184 Citations. 302 Altmetric. Metrics. Abstract. Most known pathogenic point mutations...
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Hypercompact adenine base editors based on a Cas12f variant ... - Nature
https://www.nature.com/articles/s41589-022-01077-5
WEBAug 1, 2022 · Nature Chemical Biology - A hypercompact adenine base editor termed TaRGET-ABE was developed by fusing a catalytically inactive transposon-associated transposase B guided by an engineered RNA...
DA: 91 PA: 27 MOZ Rank: 40
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Evolution of an adenine base editor into a small, efficient ... - Nature
https://www.nature.com/articles/s41587-022-01533-6
WEBNov 10, 2022 · 46 Citations. 38 Altmetric. Metrics. Abstract. Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine base...
DA: 46 PA: 26 MOZ Rank: 32
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Structure-guided engineering of adenine base editor with …
https://www.nature.com/articles/s41467-021-22519-z
WEBApr 16, 2021 · Nature Communications - Base editors can induce transcriptome-wide RNA off-target editing independent of gRNA. Here, the authors engineer ABEmax variants with minimized RNA off-target activities...
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Programmable base editing of A•T to G•C in genomic DNA ... - Nature
https://www.nature.com/articles/nature24644
WEBNov 1, 2017 · Extensive directed evolution and protein engineering resulted in seventh-generation ABEs that convert targeted A•T base pairs efficiently to G•C (approximately 50% efficiency in human cells) with...
DA: 57 PA: 49 MOZ Rank: 78
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Programmable A-to-Y base editing by fusing an adenine base ... - Nature
https://www.nature.com/articles/s41587-022-01595-6
WEBJan 9, 2023 · 53 Citations. 43 Altmetric. Metrics. Abstract. Here we developed an adenine transversion base editor, AYBE, for A-to-C and A-to-T transversion editing in mammalian cells by fusing an adenine base...
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Engineering a precise adenine base editor with minimal bystander
https://pubmed.ncbi.nlm.nih.gov/36229683/
WEBAdenine. Cytosine. RNA, Guide, CRISPR-Cas Systems. Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their bystander mutations and off-target editing effects raise safety concerns.
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A New Generation of Adenine Base Editors Improves Editing in Primary
https://blog.addgene.org/adenine-base-editors-improves-editing-in-primary-human-cells
WEBa guide RNA that targets the complex of TadA and dCas to the genomic DNA of interest. Figure 1. When ABEs are in action they bind DNA so that the TadA domain can edit the short single-stranded DNA stretch that is accessible. Image from Gaudelli et al., 2020. Directed evolution identifies adenine base editors with improved editing in cell lines.
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