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MDA5 - Wikipedia
https://en.wikipedia.org/wiki/MDA5
WEBMDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor capable of detecting viruses.
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MDA5 deficiency: MedlinePlus Genetics
https://medlineplus.gov/genetics/condition/mda5-deficiency/
WEBMDA5 deficiency is a disorder of the immune system (immunodeficiency) that leads to recurrent, severe infections of the lungs and airways (respiratory tract) beginning in infancy. Explore symptoms, inheritance, genetics of this condition.
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Dermatomyositis With Anti-MDA5 Antibodies: Bioclinical Features
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564476/
WEBOct 20, 2021 · Anti-MDA5 dermatomyositis is a rare systemic autoimmune disease, historically described in Japanese patients with clinically amyopathic dermatomyositis and life-threatening rapidly progressive interstitial lung disease. Subsequently, the complete clinical spectrum of the disease was enriched by skin, articular and vascular manifestations.
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Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and …
https://www.nature.com/articles/s41584-023-01054-9
WEBDec 6, 2023 · Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of dermatomyositis. Although the aetiology and pathology remain unclear,...
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Understanding and managing anti-MDA 5 dermatomyositis, …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000693/
WEBFeb 1, 2021 · Abstract. Anti-Melanoma Differentiation-Associated gene 5 (MDA-5) Dermatomyositis (MDA5, DM) is a recently identified subtype of myositis characteristically associated with Rapidly Progressive Interstitial Lung Disease (RP-ILD) and unique cutaneous features.
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A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319154/
WEBJun 13, 2018 · MDA5 is one such sensor of virus presence and is activated by RNA. MDA5 is required for immunity against several classes of viruses, including picornaviruses. Recent work showed that mutations in the IFIH1 gene, encoding MDA5, lead to interferon-driven autoinflammatory diseases.
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MDA5 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mda5
WEBMDA5. These proteins, MDA5, PKR, and the OASs, are all mediators of the innate immune response activated by dsRNAs, both cellular (self) and viral (non-self) RNAs. From: Encyclopedia of Biological Chemistry (Third Edition), 2021. Related terms: LGP2; RIG-I; IRF3; Interferon; Retinoic Acid; RIG-I-like Receptor; RNA; Innate Immunity; Double ...
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A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation
https://www.sciencedirect.com/science/article/pii/S0966842X18301793
WEBJan 1, 2019 · MDA5 is a pattern-recognition receptor for RNA and induces a type I interferon response. MDA5 is activated in a variety of clinically relevant settings. This includes infection with ssRNA, dsRNA, and dsDNA viruses; several autoimmune and autoinflammatory diseases, such as type 1 diabetes and Aicardi–Goutières syndrome; …
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MDA5 disease variant M854K prevents ATP-dependent structural ... - Nature
https://www.nature.com/articles/s41467-021-27062-5
WEBNov 18, 2021 · This work provides insights on how MDA5 recognizes dsRNA in health and disease. MDA5 is the primary immune sensor for SARS-CoV-2 and many other viruses. Mutations in MDA5 can cause disease.
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MDA5 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/immunology-and-microbiology/mda5
WEBIFIH1, also known as MDA5, is a cytoplasmic receptor that binds double-stranded RNA. Activation of IFIH1 is part of the inflammatory response to viral RNA replication, again resulting in the induction of type I IFN.
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