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Recent Advances in Lipopolysaccharide Recognition Systems
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013859/
WEBJan 7, 2020 · While TLR4 was thought to be the only sensor for LPS, recent studies have provided insight into two TLR4-independent LPS recognition systems: transient receptor potential (TRP) channel-dependent sensing of extracellular LPS and caspase-4/5/11-dependent sensing of intracellular LPS.
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LPS/TLR4 signal transduction pathway - PubMed
https://pubmed.ncbi.nlm.nih.gov/18304834/
WEBAbstract. The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in …
DA: 90 PA: 83 MOZ Rank: 82
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The structural basis of lipopolysaccharide recognition by the TLR4…
https://www.nature.com/articles/nature07830
WEBMar 1, 2009 · LPS binding induced the formation of an m-shaped receptor multimer composed of two copies of the TLR4–MD-2–LPS complex arranged symmetrically. LPS interacts with a large hydrophobic...
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Recognition of lipopolysaccharide pattern by TLR4 complexes
https://www.nature.com/articles/emm201397
WEBDec 6, 2013 · Lipopolysaccharide (LPS) is a well-characterized pathogen-associated molecular pattern found in the outer leaflet of the outer membrane of most of the Gram-negative bacteria. It can initiate a...
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Identification and activation of TLR4-mediated signalling ... - Nature
https://www.nature.com/articles/s41598-017-01868-0
WEBMay 10, 2017 · Among TLRs, TLR4 acts as a receptor for lipopolysaccharide (LPS), and associates with the myeloid differentiation protein 2 (MD2) to form a complex to interact with LPS 4.
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TLR4 and CD14 trafficking and its influence on LPS-induced pro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904555/
WEBOct 15, 2020 · TLR4 is activated by lipopolysaccharide (LPS, endotoxin), a major component of the outer membrane of Gram-negative bacteria. During infection, TLR4 responds to the LPS present in tissues and the bloodstream and triggers pro-inflammatory reactions facilitating eradication of the invading bacteria [ 6 ].
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Recognition of LPS by TLR4: Potential for Anti-Inflammatory …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113827/
WEBJul 23, 2014 · Where rough (R-form) LPS requires LBP and CD14, smooth (S-form) LPS has been described to directly interact with TLR4 . Upon binding of LPS to the TLR4-MD-2 complex, dimerization of this complex occurs, and signaling is initiated by the interaction of the intracellular TLR4 domains [6,10].
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LPS/TLR4 signal transduction pathway - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S1043466608000070
WEBMay 1, 2008 · The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in …
DA: 5 PA: 80 MOZ Rank: 89
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Lipopolysaccharide- TLR-4 Axis regulates ... - BMC Immunology
https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-021-00409-9
WEBMar 25, 2021 · TNF-α secreted via LPS/TLR4 signaling regulates osteoclastogenesis in macrophages primed with RANKL and then treated with LPS. Our findings suggest that TLR4/TNF-α might be a potential target to suppress bone loss associated with inflammatory bone diseases, including periodontitis, rheumatoid arthritis, and osteoporosis. Background.
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Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel
https://pubmed.ncbi.nlm.nih.gov/22363498/
WEBThe use of synthetic peptides of LPS or TLR-4 agonists, which mimic the interaction between TLR-4 and LPS, can potentially regulate cellular signal transduction pathways such that a localized inflammatory response is achieved similar to …
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