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K562 cells - Wikipedia
https://en.wikipedia.org/wiki/K562_cells
WebK562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. [1] [2] The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes [3] and erythrocytes. [4]
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K-562 - CCL-243 | ATCC
https://www.atcc.org/products/ccl-243
WebK-562 are lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukemia patient. The K-562 cell line is widely used in immune system disorder and immunology research. Product category. Human cells. Organism. Homo sapiens, human. Morphology. lymphoblast. Tissue. Bone; Marrow. Disease. Chronic …
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Characterization of K562 cells: uncovering novel chromosomes
https://link.springer.com/article/10.1007/s00018-023-04905-6
WebAbstract. Human erythroleukemic K562 cells represent the prototypical cell culture model of chronic myeloid leukemia (CML). The cells are pseudo-triploid and positive for the Philadelphia chromosome. Therefore, K562 cells have been widely used for investigating the BCR/ABL1 oncogene and the tyrosine kinase inhibitor, imatinib-mesylate.
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Genomic landscape of human erythroleukemia K562 cell line, as
https://www.sciencedirect.com/science/article/pii/S0001581417300191
WebOct 1, 2017 · Our results confirm the existence of major chromosomal aberrations in K562 cell line but we describe new mutations in several oncogenes other than BCR-ABL1 fusion gene. This confirms a high level of genomic instability in the blastic phase of CML represented by the K562 cell line.
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Comprehensive, integrated, and phased whole-genome analysis …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396411/
WebJan 22, 2018 · Abstract. K562 is widely used in biomedical research. It is one of three tier-one cell lines of ENCODE and also most commonly used for large-scale CRISPR/Cas9 screens. Although its functional genomic and epigenomic characteristics have been extensively studied, its genome sequence and genomic structural features have never …
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K562 Cells - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/k562-cells
WebIn human K562 cells derived from a patient with CML, the expression of both the normal Abl transcripts and the Bcr-Abl fusion transcript decrease approximately ten-fold when the cells are induced to differentiate with hemin Leibowitz et al (1991).
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Characterization of K562 cells: uncovering novel chromosomes
https://pubmed.ncbi.nlm.nih.gov/37578596/
WebAug 14, 2023 · Abstract. Human erythroleukemic K562 cells represent the prototypical cell culture model of chronic myeloid leukemia (CML). The cells are pseudo-triploid and positive for the Philadelphia chromosome. Therefore, K562 cells have been widely used for investigating the BCR/ABL1 oncogene and the tyrosine kinase inhibitor, imatinib-mesylate.
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Undergraduate lab series using the K562 human leukemia cell line…
https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/bmb.21222
WebFeb 6, 2019 · Because of its ease of use, versatility, and well-studied properties, the K562 cell line serves as an ideal model system to allow students to simultaneously learn about cell growth, death, adhesion, differentiation, and cancer biology.
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Cabozantinib promotes erythroid differentiation in K562 ... - Nature
https://www.nature.com/articles/s41417-021-00358-w
WebArticle. Published: 11 June 2021. Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation. Yu-Hsuan Fu,...
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High-level embryonic globin production with efficient erythroid
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541692/
WebThe K562 cell line is a well-established HEL cell line and these cells expand massively in a basic culture medium due in part to the presence of a rearranged BCR/ABL oncogene, allowing for large-scale experiments and simple cell cloning. In addition, K562 cells can be differentiated to the erythroid lineage to analyze globin expression as well ...
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