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K562 cells - Wikipedia
https://en.wikipedia.org/wiki/K562_cells
WEBK562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. [1] [2] The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes [3] and erythrocytes. [4]
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K-562 - CCL-243 | ATCC
https://www.atcc.org/products/ccl-243
WEBK-562 are lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukemia patient. The K-562 cell line is widely used in immune system disorder and immunology research.
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Characterization of K562 cells: uncovering novel chromosomes
https://link.springer.com/article/10.1007/s00018-023-04905-6
WEBAug 14, 2023 · Therefore, K562 cells have been widely used for investigating the BCR/ABL1 oncogene and the tyrosine kinase inhibitor, imatinib-mesylate. Further, K562 cells overexpress transferrin receptors (TfR) and have been used as a model for targeting cytotoxic therapies, via receptor-mediated endocytosis.
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Characterization of K562 cells: uncovering novel chromosomes
https://pubmed.ncbi.nlm.nih.gov/37578596/
WEBAug 14, 2023 · Human erythroleukemic K562 cells represent the prototypical cell culture model of chronic myeloid leukemia (CML). The cells are pseudo-triploid and positive for the Philadelphia chromosome. Therefore, K562 cells have been widely used for investigating the BCR/ABL1 oncogene and the tyrosine kinase in …
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Genomic landscape of human erythroleukemia K562 cell line, as
https://www.sciencedirect.com/science/article/pii/S0001581417300191
WEBOct 1, 2017 · We have performed detailed analysis of the genomic landscape of commercially available K562 cells, employing targeted enrichment of nearly 1300 cancer-related genes followed by next-generation sequencing (NGS) and also classical cytogenetics. Deep sequencing revealed 88 variants of potentially biological significance.
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K562 Cells - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/k562-cells
WEB1. The human lymphoblastoid cell line K-562, which was obtained from American Type Culture Collection (ATCC, Manassas, VA), has been widely used as a highly sensitive target for functional assays to evaluate NK cell antitumor activity (see Note 10 ).
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Comprehensive, integrated, and phased whole-genome analysis …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396411/
WEBJan 22, 2018 · Abstract. K562 is widely used in biomedical research. It is one of three tier-one cell lines of ENCODE and also most commonly used for large-scale CRISPR/Cas9 screens. Although its functional genomic and epigenomic characteristics have been extensively studied, its genome sequence and genomic structural features have never …
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Cabozantinib promotes erythroid differentiation in K562 ... - Nature
https://www.nature.com/articles/s41417-021-00358-w
WEBPublished: 11 June 2021. Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation. Yu-Hsuan Fu, Da-Liang Ou,...
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Tendency of K562 Chronic Myeloid Leukemia Cells Towards Cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256820/
WEBNov 13, 2018 · K562 cells were shown to express higher levels of most of the reprogramming factors and pluripotency markers. Expression of p53, which is one of the main regulators during the generation of induced pluripotent stem cells, was found to be lower in K562 cells compared to PBMCs, whereas the other tumor-suppressor genes …
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Complete karyotype characterization of the K562 cell
https://www.sciencedirect.com/science/article/pii/S0145212600001259
WEBApr 1, 2001 · Leukemia Research. Volume 25, Issue 4, 1 April 2001, Pages 313-322. Complete karyotype characterization of the K562 cell line by combined application of G-banding, multiplex-fluorescence in situ hybridization, fluorescence in situ hybridization, and comparative genomic hybridization.
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