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Jurkat cells - Wikipedia
https://en.wikipedia.org/wiki/Jurkat_cells
WEBJurkat cells are an immortalized line of human T lymphocyte cells that are used to study acute T cell leukemia, T cell signaling, and the expression of various chemokine receptors susceptible to viral entry, particularly HIV. [1] Jurkat cells can produce interleukin 2, and are used in research involving the susceptibility of cancers to drugs ...
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【细胞解读系列】揭开Jurkat细胞的神秘面纱 - 知乎
https://zhuanlan.zhihu.com/p/605233967
WEB什么是Jurkat细胞？ Jurkat细胞是一种悬浮细胞。用于研究急性T细胞白血病，T细胞信号传导以及易感病毒进入的各种趋化因子受体，特别是HIV的表达的永生化人T淋巴细胞系。它在生物学研究上具有十分广泛的应用，比如应用Jurkat细胞研究核糖核酸酶P的M1-RNA，探讨 ...
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Jurkat Cell Line - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/immunology-and-microbiology/jurkat-cell-line
WEBThe Jurkat cell line is an immortalized T lymphocyte cell line that was originally obtained from the peripheral blood of a boy with T cell leukemia [14 ]. The Jurkat cell line has most often been used as a prototypical T cell line to study multiple events in T cell biology, including a) T cell signaling and b) molecular events in the HIV ...
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Jurkat T cells and development of the T-cell receptor signalling
https://www.nature.com/articles/nri1330
WEBApr 1, 2004 · Perhaps the best known of these model systems is the Jurkat leukaemic T-cell line, and here we review some of the key advances in the field of TCR signalling that were made with Jurkat T...
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T cell activation and effector function in the human Jurkat T cell
https://pubmed.ncbi.nlm.nih.gov/37516527/
WEBIn vitro easy-to-handle cellular models are valuable tools to study intracellular molecular mechanisms in live cells. The CD4 T cell line Jurkat (JK) has been widely employed to investigate intracellular signaling leading to T cell activation in response to T cell receptor (TCR) triggering.
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Jurkat细胞模型在感染性疾病研究中的应用进展 - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389782/
WEBMar 3, 2018 · 2.1. Jurkat细胞模型在HIV感染研究中的应用. HIV是获得性免疫缺陷综合征病毒, 可特异性侵犯CD4 + T淋巴细胞, 引起CD4 + T细胞数量进行性减少和功能进行性破坏, 以及全身异常的免疫激活, 从而导致机会性感染和肿瘤。. Fas相关性死亡结构域蛋白样白细胞介素1β转变酶 ...
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CD4 and CD8 co-receptors modulate functional avidity of CD1b
https://www.nature.com/articles/s41467-021-27764-w
WEBJan 10, 2022 · The CD8 hi Jurkat cells had the highest MFI, which was 1.32-fold higher than CD8 med Jurkats and 2.35-fold higher than CD8 lo Jurkats (p = 0.0002) (Fig. 3c, middle).
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A Jurkat 76 based triple parameter reporter system to evaluate …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915142/
WEBApr 3, 2018 · Thorough characterization of genetically reprogrammed T cells is necessary to optimize treatment success. Here, we describe the generation of triple parameter reporter T cells based on the Jurkat 76 T cell line for the evaluation of TCR and chimeric antigen receptor functions as well as adoptive T cell strategies.
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Activated T cell-derived exosomal PD-1 attenuates PD-L1
https://www.nature.com/articles/s41388-021-01896-1
WEBJun 25, 2021 · To study the biological implications of Exo-PD-1 using the proper model, we first isolated exosomes derived from peripheral blood mononuclear cells (PBMCs)-derived T cells and Jurkat-T cells.
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A Jurkat 76 based triple parameter reporter system to evaluate …
https://pubmed.ncbi.nlm.nih.gov/29707134/
WEBApr 3, 2018 · Thorough characterization of genetically reprogrammed T cells is necessary to optimize treatment success. Here, we describe the generation of triple parameter reporter T cells based on the Jurkat 76 T cell line for the evaluation of TCR and chimeric antigen receptor functions as well as adoptive T cell strategies.
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