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Hereditary Spastic Paraplegia | National Institute of Neurological
https://www.ninds.nih.gov/health-information/disorders/hereditary-spastic-paraplegia
WEBDec 19, 2016 · The outlook for people with HSP varies. Some people are significantly limited and others have only mild disability. Most people with pure HSP have a normal life expectancy.
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Recent advances in understanding hereditary spastic paraplegias …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009193/
WEBMar 10, 2021 · It is one of the first symptoms in cerebellar ataxia which affect quality of life 60,61 and can lower life expectancy. It can occur in complications such as malnutrition, dehydration, and aspiration-related pneumonia.
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Hereditary spastic paraplegia - Wikipedia
https://en.wikipedia.org/wiki/Hereditary_spastic_paraplegia
WEBPrognosis. Epidemiology. References. Further reading. External links. Hereditary spastic paraplegia ( HSP) is a group of inherited diseases whose main feature is a progressive gait disorder. The disease presents with progressive stiffness ( spasticity) and contraction in the lower limbs. [1] .
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Hereditary Spastic Paraplegia - Symptoms, Causes, Treatment
https://rarediseases.org/rare-diseases/hereditary-spastic-paraplegia/
WEBJul 12, 2017 · Disease Overview. Overview. The hereditary spastic paraplegias (HSP) are a large group of inherited neurologic disorders that share the primary symptom of difficulty walking due to muscle weakness and muscle tightness (spasticity) in the legs. There are more than 80 different genetic types of HSP.
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Hereditary Spastic Paraplegia: An Update - PMC - National …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835766/
WEBFeb 1, 2022 · Linkage analysis studies revealed the 14q12 region as the prime region to induce SPG32 HSP phenotypes in consanguineous marriage families around 24 years of age with clinical manifestations including autonomic dysfunction features in the legs, with weakness, extensor plantar responses, and mental retardation [ 86 ].
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Hereditary Spastic Paraplegia - Brain, Spinal Cord, and Nerve …
https://www.msdmanuals.com/home/brain,-spinal-cord,-and-nerve-disorders/spinal-cord-disorders/hereditary-spastic-paraplegia
WEBHereditary spastic paraplegia affects both sexes and may begin at any age. It affects about 1 to 10 of 100,000 people. This disorder has many forms and can result from many different types of genetic abnormalities.
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Hereditary spastic paraplegia - NHS
https://www.nhs.uk/conditions/hereditary-spastic-paraplegia/
WEBPure hereditary spastic paraplegia does not usually affect life expectancy, and most people are able to lead relatively independent and active lives. The outlook for complicated hereditary spastic paraplegia varies between people, depending on the symptoms.
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Hereditary Spastic Paraplegia - Neurologic Disorders - Merck …
https://www.merckmanuals.com/professional/neurologic-disorders/spinal-cord-disorders/hereditary-spastic-paraplegia
WEBOnset can be at any age, from the first year of life to old age, depending on the specific genetic form. Hereditary spastic paraplegia affects both sexes. Symptoms and Signs of Hereditary Spastic Paraplegia.
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Hereditary Spastic Paraplegia | Boston Children's Hospital
https://www.childrenshospital.org/conditions/hereditary-spastic-paraplegia
WEBWhat are the symptoms of HSP? The primary symptom of HSP is difficulty walking due to spasticity and weakness in the legs. Both legs are affected, usually to a relatively similar degree. The term “paraplegia” means severe weakness in both legs (similar to “paralysis”).
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HSP : HSP & PLS : Spastic Paraplegia Foundation
https://sp-foundation.org/understanding-pls-hsp/hsp.html
WEBHereditary Spastic Paraplegia (HSP) is a group of rare, inherited neurological disorders. Their primary symptoms are progressive spasticity and weakness of the leg and hip muscles. Researchers estimate that some 90 different types of HSP exist; the genetic causes are known for about fifty.
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