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Hep G2 - Wikipedia
https://en.wikipedia.org/wiki/Hep_G2
WebHep G2 is an immortal cell line which was derived in 1975 from the liver tissue of a 15-year-old Caucasian male from Argentina with a well-differentiated hepatocellular carcinoma. [1] These cells are epithelial in morphology, have a modal chromosome number of 55, and are not tumorigenic in nude mice. [2] The cells secrete a variety of major ...
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Hep G2 [HEPG2] - HB-8065 | ATCC
https://www.atcc.org/products/hb-8065
WebHep G2 [HEPG2] is a cell line exhibiting epithelial-like morphology that was isolated from a hepatocellular carcinoma of a 15-year-old, White, male youth with liver cancer. The cell line was deposited by the Wistar Institute and is a suitable transfection host. Expression markers include insulin; insulin-like growth factor II (IGF II).
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The Curious Case of the HepG2 Cell Line: 40 Years of Expertise
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658661/
WebDec 4, 2021 · HepG2 is a popular hepatic cell line. It is used in a wide range of studies, from the oncogenesis to the cytotoxicity of substances on the liver. In this regard, we set out to collect up-to-date information on the HepG2 cell line to assess whether the level of heterogeneity of the cell line allows in vitro biomedical studies as a model with ...
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Culture and Functional Characterization of Human Hepatoma HepG2 …
https://pubmed.ncbi.nlm.nih.gov/26272135/
WebHepG2 is a human hepatoma that is most commonly used in drug metabolism and hepatotoxicity studies. HepG2 cells are nontumorigenic cells with high proliferation rates and an epithelial-like morphology that perform many differentiated hepatic functions.
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Making Cell Culture More Physiological: Global changes to HepG2 …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163570/
WebMay 5, 2021 · To address this gap in knowledge we performed transcriptomic and metabolomic analyses on human hepatocellular carcinoma (HepG2) cells adapted to either glucose or galactose as the aldohexose source. We observed a shift toward oxidative metabolism in all primary metabolic pathways at both transcriptomic and metabolomic …
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Exploring Dynamic Metabolome of the HepG2 Cell Line: Rise and …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688728/
WebNov 10, 2022 · In this technical note, we investigated the effect of prolonged cultivation of the HepG2 hepatoma cell line on its metabolomic profile. Using the GC × GC-MS approach, we determined the degree of metabolic variability across HepG2 cells cultured in uniform conditions for 0, 5, 10, 15, and 20 days.
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DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells …
https://www.nature.com/articles/s41598-022-25777-z
WebDec 7, 2022 · HepG2 cells, which are liver cancer–derived cell lines, are widely used as a human hepatocytes model. However, their functions are decreased overall compared with PHHs 3, 4, 5, 6.
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Continual proteomic divergence of HepG2 cells as a …
https://www.nature.com/articles/s41598-021-89907-9
WebMay 25, 2021 · The HepG2 spheroid proteome was divergent from the monolayer proteome after 14 days in culture and continued to change over the successive culture time points. Proteins representing the...
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Hep G2 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/hep-g2
WebHep G2 Cells. Hep G2 cells can be purchased from the American Type tissue Collection (Manassas, VA, USA, www.atcc.org ). These cells are normally cultured in minimum essential medium or Dulbecco's modified Eagle medium (DMEM) pH 7.2.
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Gene expression signature of human HepG2 cell line - PubMed
https://pubmed.ncbi.nlm.nih.gov/23357223/
WebApr 15, 2013 · HepG2 represents a pure cell line of human liver carcinoma, often used as HCC model due to the absence of viral infection. In this study we compare gene expression profiles associated with HepG2 (as HCC model) and …
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