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Structures and gating mechanisms of human bestrophin anion …
Jul 04, 2022 · In transiently transfected HEK293 cells, the whole cell currents of each chimeric channel resembled that of the corresponding channel from which the …
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Evolution from adherent to suspension: systems biology of HEK293 cell …
Nov 04, 2020 · The HEK293 cell line was originally immortalized by the random integration of viral genomic DNA of adenovirus 5 18, which includes the E1A and E1B genes.In this study, overall high mRNA levels of ...
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IFI16 directly senses viral RNA and enhances RIG-I ... - Nature
May 13, 2021 · Pull-down assays using cell lysates of HEK293 cells, separately overexpressing Flag-tagged IFI16, RIG-I, MDA-5 and TBK1 proteins, incubated with biotinylated NP vRNA showed binding of IFI16, RIG-I ...
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HEK 293 cells - Wikipedia
Human embryonic kidney 293 cells, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a specific immortalised cell line derived from a spontaneously miscarried or aborted fetus or human embryonic kidney cells grown in tissue culture taken from a female fetus in 1973.. HEK 293 cells have been widely used in cell biology research for many …
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COVID-19 Vaccines & Fetal Cell Lines - Department of Health
Dec 01, 2021 · The fetal cell lines being used to test or manufacture the COVID-19 vaccines are from two sources: HEK-293: A kidney cell line that was isolated from a fetus in 1973 (undisclosed origin, from either a spontaneous miscarriage or an elective abortion) PER.C6: A retinal cell line that was isolated from an aborted fetus in 1985
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Preclinical evaluation of FAP-2286 for fibroblast ... - SpringerLink
May 24, 2022 · Purpose Fibroblast activation protein (FAP) is a membrane-bound protease that has limited expression in normal adult tissues but is highly expressed in the tumor microenvironment of many solid cancers. FAP-2286 is a FAP-binding peptide coupled to a radionuclide chelator that is currently being investigated in patients as an imaging and …
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Circular RNA vaccines against SARS-CoV-2 and emerging variants - Cell
Mar 31, 2022 · In line with pseudovirus neutralization assay, the sera from immunized mice neutralized the authentic SARS-CoV-2 Beta and native (D614G) strains with NT50 values of 2.6 × 10 4 (Figure 1O) and 6.0 × 10 3 (Figure 1P), respectively.
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Self-generated gradients steer collective migration on ... - Nature
May 30, 2022 · Cell clusters mechanically reorganize viscoelastic collagen networks, resulting in transient gradients in collagen density, alignment and stiffness that promote spontaneous persistent migration.
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Adeno-associated virus vector as a platform for gene therapy
Feb 01, 2019 · Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids ...
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Microglial amyloid beta clearance is driven by PIEZO1 channels
Jun 15, 2022 · Background Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In late-onset AD accounting for 95% of all cases, this is thought to be due to reduced clearance of …
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