Keyword Analysis & Research: glutamine metabolism in drug resistant cancer
Keyword Analysis
| Keyword | CPC | PCC | Volume | Score | Length of keyword |
|---|---|---|---|---|---|
| glutamine metabolism in drug resistant cancer | 1.84 | 1 | 1662 | 2 | 45 |
| glutamine | 0.1 | 0.5 | 4834 | 20 | 9 |
| metabolism | 1.84 | 0.9 | 5503 | 42 | 10 |
| in | 0.44 | 0.2 | 8788 | 44 | 2 |
| drug | 1.29 | 0.4 | 1193 | 37 | 4 |
| resistant | 1.01 | 0.3 | 6725 | 32 | 9 |
| cancer | 0.74 | 0.5 | 8808 | 19 | 6 |
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Frequently Asked Questions
During malignant transformation, cancer cells modify the consumption and processing of glutamine to sustain cell growth and proliferation. In some cases, these cancer cells become addicted to glutamine. Thus, targeting the metabolism of glutamine has been developed during last years as a potential strategy against cancer.
How do cancer cells adapt their metabolic needs during glutamine deprivation?Despite that asparagine is synthetized from glutamine through asparagine synthetase, how cancer cells adapt their metabolic needs during glutamine deprivation remains to be elucidated. Glutamine metabolism and mammalian target of rapamycin complex 1 (mTORC1) pathway have a tight connection through different mechanisms.
Can a compound that blocks glutamine metabolism slow tumor growth?A compound developed by Johns Hopkins researchers that blocks glutamine metabolism can slow tumor growth, alter the tumor microenvironment and promote the production of durable and highly active anti-tumor T cells.
Is glutamine metabolism related to mTORC1 signaling?As both pathways are upregulated in many cancers, strategies which target both glutamine metabolism and mTORC1 signaling have shown synergistic effects against cell growth and proliferation [ 99].
