Keyword Analysis & Research: glutamine breast cancer


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What is glutamine metabolism in breast cancer?

Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with different morphological and molecular subtypes and responses to therapy, and breast cancer cells are known to rewire glut …

Is glutamine a hallmark of cancer?

Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells.

Does glutamine depletion affect tumor growth?

It is essential for tumor growth and marked changes in organ glutamine metabolism are characteristic of the host with cancer. Because host glutamine depletion has adverse effects, it is important to study the regulation of glutamine metabolism in cancer and to evaluate the impact of glutamine nutrition in the tumor-bearing state.

Can glutamate stop breast cancer?

In breast cancer, glutamate can disrupt homeostasis, and pathological conditions including pain. Breast cancer cells secrete high levels of glutamate, and this is linked with more bone metastases. Scientists are looking at ways of cutting glutamate production to stop cancer in its tracks!


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