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Extended-spectrum beta-lactamases - UpToDate
https://www.uptodate.com/contents/extended-spectrum-beta-lactamases
WebMar 8, 2024 · Extended-spectrum beta-lactamases (ESBLs) are enzymes that confer resistance to most beta-lactam antibiotics, including penicillins, cephalosporins, and the monobactam aztreonam. Infections with ESBL-producing organisms have been associated with poor outcomes.
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IDSA 2023 Guidance on the Treatment of Antimicrobial Resistant …
https://www.idsociety.org/practice-guideline/amr-guidance/
WebQuestion 1.1: What are preferred antibiotics for the treatment of uncomplicated cystitis caused by ESBL-E? Suggested approach : Nitrofurantoin and TMP-SMX are preferred treatment options for uncomplicated cystitis caused by ESBL-E. Ciprofloxacin, levofloxacin, and carbapenems are alternative agents for uncomplicated cystitis caused by ESBL-E.
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Treatment of extended-spectrum β-lactamase-producing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117850/
WebAug 29, 2018 · Given the World Health Organization (WHO) warning against a “post antibiotic era”, health-care providers are at a critical standpoint to find a “balance” between safe and effective ESBL-PE treatment and avoidance of inducing further resistance mechanisms.
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Extended-spectrum β-lactamases: an update on their …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284625/
WebJul 16, 2021 · Abstract. Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the early 1980s, they have spread worldwide and an are now endemic in Enterobacterales isolated from both hospital-associated and community …
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ESBL-producing Enterobacterales | HAI | CDC
https://www.cdc.gov/hai/organisms/ESBL.html
WebESBL enzymes break down and destroy some commonly used antibiotics, including penicillins and cephalosporins, and make these drugs ineffective for treating infections. This resistance means that there are fewer antibiotic options available to treat ESBL-producing Enterobacterales infections.
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Extended-spectrum beta-lactamases (ESBL): Infection and …
https://www.medicalnewstoday.com/articles/319535
WebSep 26, 2017 · Extended-spectrum beta-lactamases (ESBL) are enzymes produced by certain types of bacteria. ESBLs can break down the active ingredients in many common antibiotics, making them...
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Infectious Diseases Society of America 2022 Guidance on the …
https://academic.oup.com/cid/article/75/2/187/6570801
WebApr 19, 2022 · Infectious Diseases Society of America 2022 Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa) | Clinical Infectious Diseases | Oxford Academic. Journal …
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ESBL: Transmission, Treatments, and More - Healthline
https://www.healthline.com/health/esbl
WebApr 13, 2017 · Common antibiotics, such as cephalosporin and penicillin, are often used to treat bacterial infections. With ESBL infections, these antibiotics can become useless. Bacteria use ESBLs to become...
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Antibiotic resistance and extended spectrum beta-lactamases: …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281622/
WebAug 17, 2014 · Production of extended-spectrum β-lactamases (ESBLs) is a significant resistance-mechanism that impedes the antimicrobial treatment of infections caused by Enterobacteriaceae and is a serious threat to the currently available antibiotic armory. ESBLs are classified into several groups according to their amino acid sequence homology.
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Fact Sheet: Extended Spectrum Beta-Lactamase (ESBL) …
https://www.naccho.org/uploads/downloadable-resources/ESBL-Fact-Sheet.pdf
WebThese organisms produce an enzyme, ESBL, which can break down and destroy commonly used antibiotics such as penicillin and cephalosporins which makes them ineffective in treatment. This resistance means there are fewer antibiotic options, so intravenous therapy with a Carbapenem may be necessary.
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ESBL Antibiotics - Antibiogram & Detection
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