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Glutamine and Cancer: How It Works, What to Do - Healthline
https://www.healthline.com/health/glutamine-and-cancer
WebDec 13, 2022 · Does glutamine cause cancer? Cancer is complex. But glutamine doesn’t cause it. Many types of cancer cells do appear to use glutamine to grow and spread. But cancer itself is caused...
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Beyond Sugar: What Cancer Cells Need to Grow
https://www.mskcc.org/news/beyond-sugar-what-cancer-cells-need-grow
WebApr 24, 2019 · Cancer’s need for glutamine is so great that some cancer-causing oncogenes alter how much of it the cells take up and digest. One of the best known, the gene MYC , promotes cancer in part by increasing cancer cells’ access to a …
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Starve Cancer Cells of Glutamine: Break the Spell or Make a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627209/
WebJun 11, 2019 · In this review, we first summarize the diverse usage of glutamine to support cancer cell growth and survival, and then focus our discussion on the influence of other nutrients on cancer cell adaptation to glutamine starvation as well as its implication in cancer therapy. Keywords: glutamine, biosynthesis, amino acid starvation, adaptation ...
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Glutamine | Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/glutamine
WebFriday, September 8, 2023. Glutamine is an amino acid that can be absorbed from food sources and synthesized and stored, mainly in the muscle and the lungs. Patients with cancer and AIDS-related cachexia, or those recovering from surgery, sepsis, and intense exercise, may need to increase intake.
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A glutamine tug-of-war between cancer and immune cells: recent …
https://jeccr.biomedcentral.com/articles/10.1186/s13046-024-02994-0
WebMar 8, 2024 · Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by mounting evidence.
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Targeting glutamine metabolism as a therapeutic strategy for cancer
https://www.nature.com/articles/s12276-023-00971-9
WebApr 3, 2023 · Metrics. Abstract. Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids and metabolites via the...
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Dietary glutamine supplementation suppresses epigenetically
https://www.nature.com/articles/s41467-020-17181-w
WebJul 3, 2020 · Introduction. Despite the fact that glutamine is the most abundant amino acid in serum, several studies indicate that solid tumours, such as melanoma, pancreatic cancer, and colorectal...
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Amino acids in cancer | Experimental & Molecular Medicine - Nature
https://www.nature.com/articles/s12276-020-0375-3
WebJan 24, 2020 · Article 25 September 2020. Amino acid metabolism in tumor biology and therapy. Article Open access 13 January 2024. Glutamine reliance in cell metabolism. Article Open access 17 September 2020....
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Glutamate in cancers: from metabolism to signaling - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386414/
WebMar 9, 2019 · Glutamine and glutamate are major bioenergy substrates for normal and cancer cell growth. Cancer cells need more biofuel than normal tissues for energy supply, anti-oxidation activity and biomass production. Genes related to metabolic chains in many cancers are somehow mutated, which makes cancer cells more glutamate dependent.
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Advancing Cancer Treatment by Targeting Glutamine …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833671/
WebJan 22, 2022 · Abstract. Tumor growth and metastasis strongly depend on adapted cell metabolism. Cancer cells adjust their metabolic program to their specific energy needs and in response to an often challenging tumor microenvironment. Glutamine metabolism is one of the metabolic pathways that can be successfully targeted in cancer treatment.
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