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Apixaban - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov:443/books/NBK507910/
WEBApr 19, 2023 · Mechanism of Action. The clotting cascade is a complex process involving multiple factors acting in three defined phases: initiation, propagation, and fibrin formation. Initiation: This step occurs when the vascular endothelium and the clotting factors are disturbed.
DA: 55 PA: 70 MOZ Rank: 96
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Apixaban: Uses, Interactions, Mechanism of Action | DrugBank …
https://go.drugbank.com:443/drugs/DB06605
WEBMechanism of action. Apixaban selectively inhibits factor Xa in its free and bound forms, independant of antithrombin III Label. Apixaban also inhibits prothrominase Label. These effects prevent the formation of a thrombus Label.
DA: 97 PA: 33 MOZ Rank: 44
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Apixaban - Wikipedia
https://en.wikipedia.org:443/wiki/Apixaban
WEBMechanism of action. Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation.
DA: 70 PA: 78 MOZ Rank: 98
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Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic …
https://www.ncbi.nlm.nih.gov:443/pmc/articles/PMC6769096/
WEBMay 14, 2019 · Mode of Action. Apixaban is a potent, direct, oral, reversible, and highly selective inhibitor of FXa (inhibitory constant = 0.08 nM [0.037 ng/mL] at 25 °C) [12, 13] that does not require antithrombin III for antithrombotic activity .
DA: 9 PA: 87 MOZ Rank: 37
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Apixaban: Dosage, Mechanism/Onset of Action, Half-Life
https://www.medicine.com:443/drug/apixaban/hcp
WEBFeb 17, 2020 · Mechanism of Action Inhibits platelet activation and fibrin clot formation via direct, selective and reversible inhibition of free and clot-bound factor Xa (FXa). FXa, as part of the prothrombinase complex consisting also of factor Va, calcium ions, and phospholipid, catalyzes the conversion of prothrombin to thrombin.
DA: 5 PA: 13 MOZ Rank: 55
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Quick reference guide to apixaban - PMC - National Center for
https://www.ncbi.nlm.nih.gov:443/pmc/articles/PMC5513886/
WEBJul 10, 2017 · Apixaban is a selective factor Xa inhibitor, approved for use in the prevention of stroke in patients with nonvalvular atrial fibrillation and in the prevention and treatment of acute VTE. Like many of the DOACs, it has a fast onset of action and works to deliver predictable coagulation results.
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Apixaban (Eliquis): Mechanism of Action, Drug Comparison and Additional
https://pharmaceuticalintelligence.com:443/2014/05/10/apixaban-eliquis-mechanism-of-action-drug-comparison-and-additional-indications/
WEBMay 10, 2014 · Eliquis (apixaban) is a factor Xa inhibitor anticoagulant indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, and for the prophylaxis of deep vein thrombosis (DVT) in patients who have undergone hip or knee replacement surgery. FDA Approval History for Eliquis.
DA: 77 PA: 10 MOZ Rank: 53
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Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic Review
https://pubmed.ncbi.nlm.nih.gov:443/31089975/
WEBApixaban is an oral, direct factor Xa inhibitor that inhibits both free and clot-bound factor Xa, and has been approved for clinical use in several thromboembolic disorders, including reduction of stroke risk in non-valvular atrial fibrillation, thromboprophylaxis following hip or knee replacement surgery, the treatment of deep vein thrombosis o...
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Apixaban - Thrombosis Canada
https://thrombosiscanada.ca:443/wp-uploads/uploads/2021/12/20.-Apixaban-Eliquis_02December2021-1.pdf
WEBMECHANISM OF ACTION: Apixaban is an oral factor Xa inhibitor. By binding reversibly to the active site of factor Xa, apixaban attenuates thrombin generation and reduces fibrin formation. INDICATIONS: Apixaban is currently licensed in Canada for: Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation .
DA: 20 PA: 50 MOZ Rank: 34
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Direct Oral Anticoagulant Use: A Practical Guide to Common …
https://www.ahajournals.org:443/doi/full/10.1161/JAHA.120.017559
WEBDabigatran, rivaroxaban, apixaban, and edoxaban are approved for the lowering the risk of stroke and embolism in NVAF as well as deep vein thrombosis and pulmonary embolism treatment/prophylaxis. 8, 9, 10, 11 Unique indications include betrixaban for prophylaxis of venous thromboembolism (VTE) in hospitalized patients for an acute …
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