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Allopurinol: Uses, Interactions, Mechanism of Action - DrugBank …
https://go.drugbank.com/drugs/DB00437
WebMechanism of action. Allopurinol is a structural analog of the natural purine base, hypoxanthine. After ingestion, allopurinol is metabolized to its active metabolite, oxypurinol (alloxanthine) in the liver 11, which acts as an inhibitor of xanthine oxidase enzyme Label.
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Allopurinol - Wikipedia
https://en.wikipedia.org/wiki/Allopurinol
WebMechanism of action Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an inhibitor of the enzyme xanthine oxidase . [5] Xanthine oxidase is responsible for the successive oxidation of hypoxanthine to xanthine and subsequently uric acid , the product of …
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Allopurinol: Dosage, Mechanism/Onset of Action, Half-Life
https://www.medicine.com/drug/allopurinol/hcp
WebFeb 17, 2020 · Mechanism of Action Allopurinol inhibits xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine to uric acid. Allopurinol is metabolized to oxypurinol which is also an inhibitor of xanthine oxidase; allopurinol acts on purine catabolism, reducing the production of uric acid without disrupting the …
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Management of Gout: Update from the American College of …
https://www.aafp.org/pubs/afp/issues/2021/0800/p209.html
WebAllopurinol is the first-line urate-lowering therapy. Febuxostat (Uloric), the other xanthine oxidase inhibitor, is limited by increased cardiovascular and all-cause mortality seen in studies....
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DailyMed - ALLOPURINOL tablet
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad6950d4-2cdd-44ac-9b8a-120716460e70
WebOct 12, 2023 · Allopurinol Tablets are indicated for: The management of adults with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or ... 2 DOSAGE AND ADMINISTRATION.
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allopurinol [TUSOM | Pharmwiki] - Tulane University
https://tmedweb.tulane.edu/pharmwiki/doku.php/allopurinol
WebSep 7, 2023 · Mechanism of Action: A purine analog that inhibits xanthine oxidase, resulting in a decrease in synthesis of uric acid. Indications: The recommended first line treatment for chronic treatment of . all patients with gout (2020 American College of Rheumatology guidelines) (FitzGerald et al, 2020).
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Pharmacology of allopurinol - Wiley Online Library
https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780180733
WebPHARMACOLOGY OF ALLOPURINOL. GEORGE H. HITCHINGS. It is now 8 years since allopurinol was first introduced for commercial distribution (in England) and about 12 years since the first Phase I human studies were carried out following several years of laboratory studies. In the intervening years informa- tion about its origins, mode of action ...
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Clinical Pharmacokinetics and Pharmacodynamics of Allopurinol …
https://link.springer.com/article/10.2165/00003088-200746080-00001
WebSep 30, 2012 · Rather, the first use of allopurinol was to inhibit the xanthine oxidase-catalysed metabolism of mercaptopurine and thereby to potentiate the actions of this cytotoxic drug. [ 1] . Subsequently, allopurinol was found to decrease plasma concentrations of urate and the occurrence of acute gout.
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Allopurinol: MedlinePlus Drug Information
https://medlineplus.gov/druginfo/meds/a682673.html
WebIt works by reducing the production of uric acid in the body. High levels of uric acid may cause gout attacks or kidney stones. Allopurinol is used to prevent gout attacks, not to treat them once they occur. How should this medicine be used? Allopurinol comes as a …
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Allopurinol: Mechanism of Action & Structure | Study.com
https://study.com/academy/lesson/allopurinol-mechanism-of-action-structure.html
WebFeb 23, 2023 · Mechanism of Action of Allopurinol. Allopurinol is a classified as a xanthine oxidase inhibitor. This means that it stops the enzyme xanthine oxidase from functioning correctly. Xanthine...
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